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1

How to increase value and reduce waste when research priorities are set

Chalmers, Iain, Bracken, Michael B, Djulbegovic, Ben, Garattini, Silvio, Grant, Jonathan, Gülmezoglu, A Metin, Howells, David W, Ioannidis, John P A, Oliver, Sandy

Journal:

Year:

2014

Language:

english

File:

PDF, 429 KB

english, 2014

2

A disease looking for innovative drugs: The case of pulmonary arterial hypertension

Joppi, Roberta, Gerardi, Chiara, Bertele', Vittorio, Garattini, Silvio

Journal:

European Journal of Internal Medicine

Year:

2018

Language:

english

File:

PDF, 231 KB

english, 2018

3

Fluoxetine dose and outcome in antidepressant drug trials

Corrado Barbui, Matthew Hotopf, Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2002

Language:

english

File:

PDF, 96 KB

english, 2002

4

Caffeine disposition after oral doses

Bonati, Maurizio, Latini, Roberto, Galletti, Ferruccio, Young, John F, Tognoni, Gianni, Garattini, Silvio

Journal:

Clinical Pharmacology & Therapeutics

Year:

1982

Language:

english

File:

PDF, 579 KB

english, 1982

5

Risk : benefit assessment of old medicines

Silvio Garattini, Vittorio Bertelé

Journal:

British Journal of Clinical Pharmacology

Year:

2004

Language:

english

File:

PDF, 144 KB

english, 2004

6

Neurochemical Mechanism of Action of Anorectic Drugs

Rosario Samanin, Silvio Garattini

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1993

Language:

english

File:

PDF, 720 KB

english, 1993

7

Smoking in Italy 2005–2006: Effects of a comprehensive National Tobacco Regulation

Silvano Gallus, Piergiorgio Zuccaro, Paolo Colombo, Giovanni Apolone, Roberta Pacifici, Silvio Garattini, Cristina Bosetti, Carlo La Vecchia

Journal:

Preventive Medicine

Year:

2007

Language:

english

File:

PDF, 150 KB

english, 2007

8

Competition for academic promotion in Italy

Silvio Garattini

Journal:

Year:

2001

Language:

english

File:

PDF, 40 KB

english, 2001

9

Homoeopathy: not a matter for drug-regulatory authorities

Silvio Garattini, Vittorio Bertelé

Journal:

Year:

2009

Language:

english

File:

PDF, 89 KB

english, 2009

10

Clinical Pharmacokinetics of Diazepam

Marinella Mandelli,Gianni Tognoni,Silvio Garattini

Journal:

Clinical Pharmacokinetics

Year:

1978

Language:

english

File:

PDF, 1.36 MB

english, 1978

11

More on homeopathy

Garattini, Silvio

Journal:

European Journal of Internal Medicine

Year:

2015

Language:

english

File:

PDF, 119 KB

english, 2015

12

Progress of anticancer drugs in reducing mortality from selected cancers in Europe

Vecchia, Carlo La, Levi, Fabio, Lucchini, Franca, Garattini, Silvio

Journal:

Anti-Cancer Drugs

Year:

1991

File:

PDF, 496 KB

1991

13

Divergent effects of macrophage toxins on growth of primary tumors and lung metastases in mice

Alberto Mantovani, Raffaella Giavazzi, Nadia Polentarutti, Federico Spreafico, Silvio Garattini

Journal:

International Journal of Cancer

Year:

1980

Language:

english

File:

PDF, 405 KB

english, 1980

14

Biliary excretion of conjugated hydroxyl benzodiazepines after administration of several benzodiazepines to rats, guinea pigs, and mice

Paolo Bertagni, Franca Marcucci, Emilio Mussini, Silvio Garattini

Journal:

Journal of Pharmaceutical Sciences

Year:

1972

Language:

english

File:

PDF, 218 KB

english, 1972

15

Metabolism and anticonvulsant activity of deuterated N-demethyldiazepam

Franca Marcucci, Emilio Mussini, Paola Martelli, Amalia Guaitani, Silvio Garattini

Journal:

Journal of Pharmaceutical Sciences

Year:

1973

Language:

english

File:

PDF, 334 KB

english, 1973

16

Announcement

Silvio Garattini, Alfredo Leonardi

Journal:

Bioorganic Chemistry

Year:

1976

Language:

english

File:

PDF, 54 KB

english, 1976

17

The absorption by human volunteers of glutamic acid from monosodium glutamate and from a partial enzymic hydrolysate of casein

Timothy C. Marrs, Mario Salmona, Silvio Garattini, David Burston, David M. Matthews

Journal:

Year:

1978

Language:

english

File:

PDF, 389 KB

english, 1978

18

Inflammatory cytokines and related genes are induced in the rat hippocampus by limbic status epilepticus

Maria Grazia De Simoni, Carlo Perego, Teresa Ravizza, Daniela Moneta, Mirko Conti, Francesco Marchesi, Ada De Luigi, Silvio Garattini, Annamaria Vezzani

Journal:

European Journal of Neuroscience

Year:

2000

Language:

english

File:

PDF, 1.49 MB

english, 2000

19

The case of gissi in changing the attitudes and practice of Italian cardiologists

Gianni Tognoni, Maria Grazia Franzosi, Silvio Garattini, Aldo Maggioni, Antonio Lotto, Francesco Mauri, Fausto Rovelli

Journal:

Statistics in Medicine

Year:

1990

Language:

english

File:

PDF, 637 KB

english, 1990

20

Review perspectives in the treatment of cancer metastasis

Silvio Garattini

Journal:

Clinical and Experimental Metastasis

Year:

1987

Language:

english

File:

PDF, 1.09 MB

english, 1987

21

In vitro and in vivo effects of the anorectic agent dexfenfluramine on the central serotoninergic neuronal systems of non-human primates. A comparison with the rat

Tiziana Mennini, Claudia Fracasso, Alfredo Cagnotto, Alessandra Bergami, Emanuela Frittoli, Marco Gobbi, Silvio Caccia, Silvio Garattini

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1996

Language:

english

File:

PDF, 831 KB

english, 1996

22

Anorectic effect of fenfluramine isomers and metabolites: Relationship between brain levels and in vitro potencies on serotonergic mechanisms

Tiziana Mennini, Silvio Garattini, Silvio Caccia

Journal:

Psychopharmacology

Year:

1985

Language:

english

File:

PDF, 390 KB

english, 1985

23

Pharmacokinetics of fotemustine and BCNU in plasma, liver and tumor tissue of rats bearing two lines of Walker 256 carcinoma

Amalia Guaitani, Monica Corada, Catherine Lucas, Antoinette Lemoine, Silvio Garattini, Ivan Bartošek

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1991

Language:

english

File:

PDF, 514 KB

english, 1991

24

Prognosis of untreated patients with idiopathic membranous nephropathy

Arrigo Schieppati, Lidia Mosconi, Annalisa Perna, Giuliano Mecca, Tullio Bertani, Silvio Garattini, Giuseppe Remuzzi

Journal:

Pediatric Nephrology

Year:

1994

Language:

english

File:

PDF, 108 KB

english, 1994

25

Obituary

Caterina Bendotti, Mirjana Carli, Silvio Garattini

Journal:

Psychopharmacology

Year:

2001

Language:

english

File:

PDF, 20 KB

english, 2001

26

Varying and "atypical" indications for atypical antipsychotics

Corrado Barbui, Michele Tansella, Silvio Garattini

Journal:

Psychopharmacology

Year:

2003

Language:

english

File:

PDF, 76 KB

english, 2003

27

CNS drugs approved by the centralised European procedure: true innovation or dangerous stagnation?

Corrado Barbui, Andrea Cipriani, Camilla Lintas, Vittorio Bertelé, Silvio Garattini

Journal:

Psychopharmacology

Year:

2007

Language:

english

File:

PDF, 79 KB

english, 2007

28

Efficacy, safety and cost of new drugs acting on the central nervous system

Silvio Garattini, Vittorio Bertele'

Journal:

European Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 181 KB

english, 2003

29

Efficacy, safety and cost of new cardiovascular drugs: a survey

Silvio Garattini, Vittorio Bertele'

Journal:

European Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 166 KB

english, 2003

30

Bench to bedside

Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 42 KB

english, 2006

31

Designing the most favourable study design

Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2005

Language:

english

File:

PDF, 101 KB

english, 2005

32

Haematological anticancer drugs in Europe: any added value at the time of approval?

Vittorio Bertele’, Rita Banzi, Filippo Capasso, Giovanni Tafuri, Francesco Trotta, Giovanni Apolone, Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 141 KB

english, 2007

33

Efficacy and safety of immunosuppressive drugs approved in EU through the centralised procedure

Vittorio Bertele’, Carmela Buonocore, Francesca Michelacci, Maria Vitocolonna, Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 120 KB

english, 2007

34

New antirheumatic drugs: any real added value? A critical overview of regulatory criteria for their marketing approval

Vittorio Bertele’, Alessandro Assisi, Valeria Di Muzio, Danila Renzo, Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

35

Do we learn the right things from clinical trials?

Silvio Garattini, Vittorio Bertele’

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 195 KB

english, 2008

36

Enhancing the rational use of new medicines across European health care systems

Silvio Garattini, Vittorio Bertele’, Brian Godman, Alan Haycox, Björn Wettermark, Lars L. Gustafsson, The Piperska Group

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 69 KB

english, 2008

37

Limits of add-on trials: antirheumatic drugs

Laura Ottolenghi, Vittorio Bertele’, Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 149 KB

english, 2009

38

Anything new in EU pharmacovigilance?

Silvio Garattini, Vittorio Bertele’

Journal:

European Journal of Clinical Pharmacology

Year:

2011

Language:

english

File:

PDF, 73 KB

english, 2011

39

Time to revisit the orphan drug law

Silvio Garattini

Journal:

European Journal of Clinical Pharmacology

Year:

2012

Language:

english

File:

PDF, 42 KB

english, 2012

40

Orphan drug development is progressing too slowly

Roberta Joppi, Vittorio Bertele, Silvio Garattini

Journal:

British Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 93 KB

english, 2006

41

Orphan drug development is not taking off

Roberta Joppi, Vittorio Bertele, Silvio Garattini

Journal:

British Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 605 KB

english, 2009

42

Mild depression in general practice: is the automatism of antidepressant prescribing an evidence-based approach?

Corrado Barbui, Silvio Garattini

Journal:

Acta Psychiatrica Scandinavica

Year:

2006

Language:

english

File:

PDF, 67 KB

english, 2006

43

Italy must invest more in science and technology

Bertini, Ivano, Garattini, Silvio, Rappuoli, Rino

Journal:

Year:

2008

Language:

english

File:

PDF, 67 KB

english, 2008

44

Reduction of beta-adrenergic receptors by tertatolol: An additional mechanism for beta-adrenergic blockade

Blasi, Antonio De, Lipartiti, Maria, Rochat, Catherine, Prost, Jean-françois, Garattini, Silvio

Journal:

Clinical Pharmacology & Therapeutics

Year:

1986

Language:

english

File:

PDF, 856 KB

english, 1986

45

Catecholamine receptor binding in rat kidney: Effect of aging

Galbusera, Miriam, Garattini, Silvio, Remuzzi, Giuseppe, Mennini, Tiziana

Journal:

Kidney International

Year:

1988

Language:

english

File:

PDF, 499 KB

english, 1988

46

Oral zeranol shortens the prolonged bleeding time of uremic rats

Zoja, Carla, Viganò, Gianluigi, Corna, Daniela, Salmona, Mario, Remuzzi, Giuseppe, Garattini, Silvio

Journal:

Kidney International

Year:

1990

Language:

english

File:

PDF, 438 KB

english, 1990

47

Methylprednisolone dosage effects on peripheral lymphocyte subpopulations and eicosanoid synthesis

Rota, Stefano, Rambaldi, Alessandro, Gaspari, Flavio, Noris, Marina, Daina, Erica, Benigni, Ariela, Perna, Annalisa, Donadelli, Roberta, Remuzzi, Giuseppe, Garattini, Silvio

Journal:

Kidney International

Year:

1992

Language:

english

File:

PDF, 1.02 MB

english, 1992

48

Thrombolysis or nothing for acute myocardial infarction? It's all the same!

Vittorio Bertele', Laura Angelici, Simona Barlera, Silvio Garattini

Journal:

British Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 367 KB

english, 2008

49

Toxic Effects of Chemicals: Difficulties in Extrapolating Data from Animals to Man

Garattini, Silvio

Journal:

Critical Reviews in Toxicology

Year:

1985

Language:

english

File:

PDF, 1.98 MB

english, 1985

50

Anorectic effect and brain concentrations of D-fenfluramine in the marmoset: relationship to the in vivo and in vitro effects on serotonergic mechanisms

Silvio Caccia, Marina Anelli, Claudia Fracasso, Emanuela Frittoli, Paolo Giorcelli, Marco Gobbi, Carlo Taddei, Silvio Garattini, Tiziana Mennini

Journal:

Naunyn-Schmiedeberg's Archives of Pharmacology

Year:

1993

Language:

english

File:

PDF, 738 KB

english, 1993

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